Results of the study confirm that vitamin d supplementation has a role in reducing blood pressure in hypertensive patients and that it should be. For each 10 ngml more vitamin d, 12% lower risk of developing hypertension. Vitamin d deficiency and essential hypertension request pdf. A study of serum vitamin d level and its association with.
Plasma 25hydroxyvitamin d levels and risk of incident hypertension. Vitamin d and hypertension organic lifestyle magazine. The evidence on the association between baseline vitamin d status and risk of incident hypertension in general populations is limited and has not been reliably quantified. While there is strong evidence that vitamin d plays an important role in maintaining bone and muscle. Vitamin d deficiency is a risk factor for arterial hypertension, but randomized controlled trials showed mixed effects of vitamin d. Vitamin d is very important for overall health and wellbeing. Measurement of 25hydroxyvitamin d in the blood and not 1,25dihydroxyvitamin d is used to determine vitamin d status. High blood pressure directly increases the risk of coronary heart disease which leads to heart attack and stroke, especially when its present with other risk factors.
Looking at vitamin ds role in blood pressure dummies. Importance low levels of vitamin d are associated with elevated blood pressure bp and future cardiovascular events. Lowfat milk products were inversely associated with hypertension incidence, with a pooled relative risk of 0. Positive and negative experiences from patients with pulmonary hypertension that take vitamin b12. However, some trials have failed to support the impact of vitamin d on reducing hypertension 11,12. Worldwide, about 4 out of 10 people have hypertension. Plasma 25oh d levels are inversely and independently associated with the risk of developing hypertension. Some inconsistent results from studies of the relationship between vitamin d status and arterial hypertension have been reported, possibly because the effects of 25oh d on blood pressure are not apparent in normotensive individuals with 25oh d levels within the normal range. Effects of vitamin d on blood pressure and cardiovascular risk. When there is an unstable balance, vitamin d deficiency as an epigenetic factor triggers a shift to the side of vasoconstriction. For every 10 ngml increase in vitamin d status there was a 12% decreased risk of hypertension. Hypertension, also known as high blood pressure, is the leading cause of heart disease worldwide 2. Effects of vitamin d on renin expression in hypertensive patients the safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
Antioxidants may help to promote vasodilation, reducing pressure on the arteries. This might surprise you but studies have described the link between the two. This study will assess whether aliskiren will lower clinic blood pressure and 24hour blood pressure in patients with hypertension and vitamin d deficiency. Take vitamin bcomplex, c and e for high blood pressure alvin hopkinson patient expert may 8, 2009 when you take a multivitamin and mineral. A new study, presented at the european society of hypertension meeting in london, shows that vitamin d supplementation in winter can help lower blood pressure in patients with hypertension. Hypertension and vitamin d search hypertension, intervention, vitamin d 24 studies as of jan 2015 reduce cardiac damage 50,000 iu vitamin d every 2 weeks patients with hypertension 3,000 iu daily for 6 weeks 2360 iu average reduced systolic blood pressure in clinical trial 2011 role of vitamin d supplementation in hypertension. Hypertension, vitamin d, and vitamin d receptor aug 2019 hypertension 2x more likely as a youth if low vitamin d for first 3 years of life june 2019 increased health problems in blacks is similar to that of low vitamin d whites john singleton stroke. Additionally, this study will further explore the potential additional effects of adding vitamin d to aliskiren in this patient population. Vitamin d and hypertension september 8, 2015 by allene edwards last updated on.
According to research published in the journal hypertension in 2001, the antioxidant properties of vitamin e decrease blood pressure. Vitamin d, hypertension and blood pressure dairy nutrition. Only threefourths of those who have high blood pressure are aware of their condition. The results of this analysis do not support the use of vitamin d as an individual patient treatment for hypertension, the researchers write. Risk for heart disease and stroke increases across a range of blood pressures, with substantial risk attributed to even highnormal blood pressure levels 1. Its too early to say whether a lack of vitamin d causes high blood pressure, or whether vitamin d supplements may have any role in the treatment of high blood pressure.
Jul 17, 2014 low levels of vitamin d may be a cause of high blood pressure, according to a new study. Researchers pooled 35 studies of nearly 100,000 people with a european background. Vitamin d and hypertension abstract high blood pressure is very prevalent worldwide, as well as vitamin d deficiency. Cureus does vitamin d deficiency lead to hypertension. Vitamin d has the pleiotropic effects in multiple organ systems, and vitamin d deficiency was suggested to be associated with high blood pressure according to previous reports. But dont worry, vitamin d doesnt raise blood pressureon the contrary, it can help lower it, and people with high blood pressure, or hypertension, may want to consider taking a natural and active supplement in the form of vitamin d3, also called cholecalciferol. In a transgenic mouse model with mice overexpressing the human vitamin d receptor in reninproducing cells, kong et al. Link between vitamin d and hypertension not yet completely understood april 2011 2x more likely to have hypertension if less than 15 ng march 2011 prediabetes and hypertension 2. When the results were analysed, they found a significant link.
These recommendations may or may not apply to your individual health condition. Take vitamin bcomplex, c and e for high blood pressure. For references and more information, see the sections on hypertension in the vitamin c article. Vitamin d is an essential nutrient for the human body. Vitamin d supplementation might improve hypertension. A randomized, doubleblind, placebocontrolled study led by a team of doctors from brigham and womens hospital in boston, for example, showed that taking vitamin d3. Hypertension htn or high blood pressure is one of the most chronic and deadliest disorders in the world. People are not meeting these levels through diet alone from e. Which of the following is associated with the highest global burden of disease. Out of 283,500 subjects, 33,800 people reported hypertension, or high blood pressure, during followup. Vitamin d and omega3 hypertension trial vital hypertension. In addition to its important role in skeletal development and calcium homeostasis, several recent studies suggest its association with diabetes, hypertension, cardiovascular disease, certain types of malignancy, and immunologic dysfunction.
For each 10 percent increase in vitamin d levels, there was an 8 percent decrease in the risk of developing high blood pressure or hypertension. Hypertensive crises are acute, severe elevations in blood. Effect of vitamin d supplementation on blood pressure in blacks. Reviews by patients who have pulmonary hypertension and take vitamin b12 either as part of daily diet or as method of treatment. Since the 1997 dietary reference intake dri values for vitamin d and calcium were established new data have become available on their relationship, both individually and combined, to a wide range of health outcomes. Vitamin d is a steroid prohormone synthesized in the skin following ultraviolet exposure and also achieved. They therefore concluded that lower vitamin d levels are independently associated with a higher risk of incident hypertension. The paper reports on new research into genetic variations associated with low vitamin d levels and their relationship with blood pressure. Causal link between vitamin d deficiency, hypertension.
Its possible that taking vitamin d supplements might help lower your blood pressure by. William white and pooja luthra at the university of connecticut health center are investigating a possible link between vitamin d deficiency and high blood pressure. The information should be used in conjunction with the guidance and care of your physician. Effects of vitamin d on renin expression in hypertensive patients. Apr 14, 2020 while the latest studies to examine vitamin d as a natural remedy for high blood pressure have been positive, the truth is that results from studies thus far have been mixed. Listing a study does not mean it has been evaluated by the u. Vitamin d is also sometimes recommended as a treatment for hypertension that has already developed, though research evidence for this use is not strong. Mar 16, 2015 vitamin d wont help fight high blood pressure. Mixed findings with vitamin d in hypertension medscape. Hypertension was found to be significantly higher in the q3 population, and it is recognized that vitamin d deficiency is associated with hypertension and repletion has an antihypertensive effect.
Low vitamin d levels linked to high blood pressure webmd. Considering that sunlight exposure of the skin is required for endogenous vitamin d synthesis, the initial speculations on a possible relationship of vitamin d and arterial hypertension were based on the observation that the prevalence of arterial hypertension is low in sunny regions, but decreases with increasing distance from the equator 46. Forman t he prevalence of vitamin d insufficiency, defined by a 25hydroxyvitamin d 25oh d level 30 ngml, in the united states was 77% in 2004. Effects of vitamin d on renin expression in hypertensive. Usually, doctors will treat vitamin d deficiency with about 50,000 ius per week which is about 7000 ius per day. New genetic research provides compelling evidence that low levels of. Vitamin d deficiency and essential hypertension sciencedirect. One of the risk factors we would like to highlight is low vitamin d levels. There are many risk factors responsible for htn which include age, race, using tobacco, high salt intake, etc. Monday, march 16, 2015 healthday news vitamin d may help the body in many ways, but a new data. Vitamin d is also sometimes recommended as a treatment for hypertension that has already developed, though research evidence for. Such a result may prove to be significant in the treatment of hypertension, as even modest blood pressure reductions 5 mmhg are associated with a 14% reduction in mortality due to stroke, a 9% reduction in mortality due to chd, and a 7% overall reduction in allcause. In the united states, 1 out of every 3 adults has hypertension recent research.
Vitamin d supplements can reduce blood pressure in. New genetic research provides compelling evidence that. Several interventional studies have examined the effect of vitamin d supplementation on high blood pressure patients, but the results have. Vitamin d is a fatsoluble vitamin that helps maintain calcium and phosphorus balance, promotes bone health and immune function, and influences cell growth and development. Sellers of vitamin d claim the nutrient can lower your blood pressure. There are several observation data that support the concept that vitamin d is involved in pathogenesis of hypertension. Joint association of low vitamin d and vitamin k status with blood. In general, evidence for the antihypertensive effects of vitamin d. Vitamin d and pulmonary hypertension prague medical report vol. Whether vitamin d supplementation reduces bp and which patient characteristics predict a response remain unclear. Jun 26, 2014 for each 10 percent increase in vitamin d levels, there was an 8 percent decrease in the risk of developing high blood pressure or hypertension. A major source of vitamin d comes from exposure to sunlight.
Dietary sodium and increased activity of the ras are known to contribute to hypertension. In view of the costs and side effects associated with antihypertensive drugs, the potential to prevent or reduce blood pressure and therefore the risk of hypertension with vitamin d is very attractive, study leader elina hypponen, a professor from the university of south australia, said in a journal news release. Levels of vitamin d supplementation required to reach such levels vary widely depending on age, sex, obesity, and baseline 25ohd levels. Previous studies report an association between vitamin d deficiency and hypertension, including the pregnancyspecific preeclampsia. Nov 10, 2009 thus, vitamin d deficiency may increase the risk of hypertension, and vitamin d supplementation may be beneficial to the cardiovascular system. Vitamin d deficiency and hypertension are linked to each other. Physicians explore link between vitamin d deficiency and. Vitamin d, sometimes called the sun vitamin because our bodies use sun exposure to manufacture vitamin d, might prevent the development of hypertension. This balance is controlled by the interaction of genetic and epigenetic factors. High blood pressure is exceedingly common in the united states, occurring in one of every four people, or 75 million americans. The relation between serum vitamin d levels and blood. The vitamin d level in the hypertensive group was 22. Nct 01169259 is an ongoing randomized clinical trial in 25,875 u.
Assessment of vitamin d status in patients with essential. Jun 25, 2014 causal link between vitamin d deficiency, hypertension suggested by researchers date. Review association of vitamin d levels and hypertension. Sep 08, 2015 vitamin d and hypertension september 8, 2015 by allene edwards last updated on. Role of vitamin d supplementation in hypertension ncbi. Some inconsistent results from studies of the relationship between vitamin d status and arterial hypertension have been reported, possibly because the effects of 25ohd on blood pressure are not apparent in normotensive individuals with 25ohd levels within the normal range. When dcardia and consortia data for hypertension were metaanalysed together n142 255, the synthesis score was associated with a reduced odds of hypertension or per allele, 098, 096099. The authors found that having vitamin d levels among the top onethird of participants decreased the risk of hypertension by 30%. There was a significant inverse linear association between the consumption of milk and incident hypertension, with a pooled relative risk of 0.
New advice on vitamin d from public health england phe, says that children and adults over the age of one should have 10 micrograms mcg of vitamin d every day. High blood pressure linus pauling institute oregon state. Vitamin d deficiency may be linked to heart disease and an increased risk of high blood pressure hypertension. The impact of vitamin d in the treatment of essential hypertension. The relationship between vitamin d deficiency and pulmonary. Researchers believe that because vitamin e is an antioxidant, taking it as a supplement may reduce oxidative stress, improve. Blacks have significantly higher rates of hypertension than whites, and lower circulating levels of 25hydroxyvitamin d.
This article will bring forward the importance of vitamin d and its role in maintaining blood pressure levels. Vitamin d may be a natural remedy for high blood pressure. Several interventional studies have examined the effect of vitamin d supplementation on high blood pressure patients, but the results have been inconsistent. Mehta suggested that low levels of vitamin d, along with sugar and fats, should be considered as new risk factors in causing hypertension 14. This sheet is a compilation of recommendations by top researchers. Apr 25, 2012 a new study, presented at the european society of hypertension meeting in london, shows that vitamin d supplementation in winter can help lower blood pressure in patients with hypertension. Vitamin d wont help fight high blood pressure webmd. Vitamin d supplements can reduce blood pressure in patients. The difference was statistically significant p value 0. Genetic research clarifies link between hypertension and. The relationship between vitamin d and blood pressure.
The fact that 1,25oh2d3 suppresses the expression of the renin gene 9 could provide an explanation for the documented inverse relationship between vitamin d and blood pressure 10. Vitamin d deficiency in patients with hypertension full. Causal link between vitamin d deficiency, hypertension suggested by researchers date. High blood pressure linus pauling institute oregon. Circulating 25ohd is converted by renal or extrarenal 1. More important, the nutrient is a diuretic which means it helps eliminate excess water in the body and, along with it, excess sodium, a mechanism that efficiently. Vitamin d deficiency linked to high blood pressure nhs. Despite claims from the nutrition industry and nonmedical personnel about vitamin d s. This fact sheet does not constitute medical advice.
Also some clinical date demonstrate positive effect of vitamin d therapy on hypertension. September 8, 2015 one in three american adults has high blood pressure, a condition that increases the risk of heart disease the number one cause of death in the u. Among the subset of 92 patients who were vitamind deficient at the start of the study, vitamind supplementation did reduce systolic and diastolic 24hour abp. Or are you using prescription vitamin d that you got from the pharmacy with a doctors prescription that is vitamin d2.
There are no indian studies regarding the study of vitamin d in hypertension or other cardiovascular diseases. Serum levels of vd3 are mainly determined by renal vd3 production, which is closely associated with calcium homeostasis and parathyroid. Nevertheless, the missing association of vitamin d and hypertension. Essential hypertension eh results when the balance between vasoconstriction and vasodilation is shifted in favor of vasoconstriction. Vitamin c for cardiovascular health helps maintain the elasticity of the blood vessels it is responsible for collagen production and helps cleanse them of cholesterol deposits.
Vitamin d may be used to help prevent or treat high blood pressure. Effect of vitamin d supplementation on blood pressure. Plasma 25hydroxyvitamin d levels and risk of incident hypertension among young women. The combination of low vitamin d and k status was associated with increased blood pressure and a trend for greater hypertension risk. Vitamin d and hypertension current evidence and future directions anand vaidya, john p. Previous research has suggested a strong link between low levels of vitamin d and high blood pressure, but a direct cause and effect relationship has not been shown. Vitamin d deficiency is widely prevalent across all ages, races, geographical regions, and socioeconomic strata. Vitamin d supplements could help high blood pressure, the independent reports. While the latest studies to examine vitamin d as a natural remedy for high blood pressure have been positive, the truth is that results from studies thus far have been mixed.
695 996 967 1377 1237 734 1421 453 1190 1298 200 1080 1077 1217 1335 814 299 834 880 146 470 370 1137 1267 1378 173 1025 228 1293 843 145 516 45 435 780 700 1495 786 551 538 1063 312